gentoo resync : 12.03.2021

33 files changed, 74 insertions, 83 deletions

diff --git a/metadata/md5-cache/sci-biology/HTSeq-0.12.4 b/metadata/md5-cache/sci-biology/HTSeq-0.12.4
index b4a2297f70ab..1b8401abd42f 100644
--- a/metadata/md5-cache/sci-biology/HTSeq-0.12.4
+++ b/metadata/md5-cache/sci-biology/HTSeq-0.12.4
@@ -11,5 +11,5 @@ RDEPEND=dev-python/numpy[python_targets_python3_7(-)?,python_targets_python3_8(-
 REQUIRED_USE=|| ( python_targets_python3_7 python_targets_python3_8 python_targets_python3_9 )
 SLOT=0
 SRC_URI=https://github.com/htseq/htseq/archive/release_0.12.4.tar.gz -> HTSeq-0.12.4.tar.gz
-_eclasses_=distutils-r1	c166cdc9bfdc0fee3ea2100e01fdcdd3	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	python-r1	4c65b35c1895b82c0f44e44166a3464f	python-utils-r1	69861348186337fa4b269de5826004b3	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
+_eclasses_=distutils-r1	16579e06f8839831bd5c03455bb87e3f	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	python-r1	6d099888c5b4dd4868c26508df307e95	python-utils-r1	2dc8e06a3429719b43e9140f7292a425	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
 _md5_=ae9941d3e3234244619fdcb2b46c8e90
diff --git a/metadata/md5-cache/sci-biology/HTSeq-9999 b/metadata/md5-cache/sci-biology/HTSeq-9999
index b8b2aa7d4a82..c2be060327dc 100644
--- a/metadata/md5-cache/sci-biology/HTSeq-9999
+++ b/metadata/md5-cache/sci-biology/HTSeq-9999
@@ -10,5 +10,5 @@ PROPERTIES=live
 RDEPEND=dev-python/numpy[python_targets_python3_7(-)?,python_targets_python3_8(-)?,python_targets_python3_9(-)?,-python_single_target_python3_7(-),-python_single_target_python3_8(-),-python_single_target_python3_9(-)] dev-python/matplotlib[python_targets_python3_7(-)?,python_targets_python3_8(-)?,python_targets_python3_9(-)?,-python_single_target_python3_7(-),-python_single_target_python3_8(-),-python_single_target_python3_9(-)] sci-biology/pysam[python_targets_python3_7(-)?,python_targets_python3_8(-)?,python_targets_python3_9(-)?,-python_single_target_python3_7(-),-python_single_target_python3_8(-),-python_single_target_python3_9(-)] python_targets_python3_7? ( dev-lang/python:3.7 ) python_targets_python3_8? ( dev-lang/python:3.8 ) python_targets_python3_9? ( dev-lang/python:3.9 ) >=dev-lang/python-exec-2:=[python_targets_python3_7(-)?,python_targets_python3_8(-)?,python_targets_python3_9(-)?,-python_single_target_python3_7(-),-python_single_target_python3_8(-),-python_single_target_python3_9(-)]
 REQUIRED_USE=|| ( python_targets_python3_7 python_targets_python3_8 python_targets_python3_9 )
 SLOT=0
-_eclasses_=distutils-r1	c166cdc9bfdc0fee3ea2100e01fdcdd3	git-r3	3e7ec3d6619213460c85e2aa48398441	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	python-r1	4c65b35c1895b82c0f44e44166a3464f	python-utils-r1	69861348186337fa4b269de5826004b3	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
+_eclasses_=distutils-r1	16579e06f8839831bd5c03455bb87e3f	git-r3	3e7ec3d6619213460c85e2aa48398441	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	python-r1	6d099888c5b4dd4868c26508df307e95	python-utils-r1	2dc8e06a3429719b43e9140f7292a425	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
 _md5_=ae9941d3e3234244619fdcb2b46c8e90
diff --git a/metadata/md5-cache/sci-biology/Manifest.gz b/metadata/md5-cache/sci-biology/Manifest.gz
index 5f1e906c79c8..6579b729d3f6 100644
--- a/metadata/md5-cache/sci-biology/Manifest.gz
+++ b/metadata/md5-cache/sci-biology/Manifest.gz
diff --git a/metadata/md5-cache/sci-biology/bcftools-1.10.2 b/metadata/md5-cache/sci-biology/bcftools-1.10.2
index 0fe2015598f2..d17e2e27b5bc 100644
--- a/metadata/md5-cache/sci-biology/bcftools-1.10.2
+++ b/metadata/md5-cache/sci-biology/bcftools-1.10.2
@@ -10,5 +10,5 @@ RDEPEND=dev-lang/perl python_single_target_python3_7? ( dev-python/matplotlib[py
 REQUIRED_USE=^^ ( python_single_target_python3_7 python_single_target_python3_8 python_single_target_python3_9 )
 SLOT=0
 SRC_URI=https://github.com/samtools/bcftools/releases/download/1.10.2/bcftools-1.10.2.tar.bz2
-_eclasses_=multilib	d410501a125f99ffb560b0c523cd3d1e	python-single-r1	d3100de905f978df912135806cf27188	python-utils-r1	69861348186337fa4b269de5826004b3	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
+_eclasses_=multilib	d410501a125f99ffb560b0c523cd3d1e	python-single-r1	d3100de905f978df912135806cf27188	python-utils-r1	2dc8e06a3429719b43e9140f7292a425	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
 _md5_=2fd4d2217632ea38f3b2adae16fec9fb
diff --git a/metadata/md5-cache/sci-biology/bedtools-2.29.2 b/metadata/md5-cache/sci-biology/bedtools-2.29.2
index 3a84c8f6c4db..78b0ffe1b9c6 100644
--- a/metadata/md5-cache/sci-biology/bedtools-2.29.2
+++ b/metadata/md5-cache/sci-biology/bedtools-2.29.2
@@ -11,5 +11,5 @@ RDEPEND=app-arch/bzip2 app-arch/xz-utils sys-libs/zlib
 RESTRICT=!test? ( test )
 SLOT=0
 SRC_URI=https://github.com/arq5x/bedtools2/releases/download/v2.29.2/bedtools-2.29.2.tar.gz
-_eclasses_=multilib	d410501a125f99ffb560b0c523cd3d1e	python-any-r1	0a79a9b53fce4525f438f8ea9695fb88	python-utils-r1	69861348186337fa4b269de5826004b3	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
+_eclasses_=multilib	d410501a125f99ffb560b0c523cd3d1e	python-any-r1	0a79a9b53fce4525f438f8ea9695fb88	python-utils-r1	2dc8e06a3429719b43e9140f7292a425	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
 _md5_=f3eef2425b0d021201cd5bb705836375
diff --git a/metadata/md5-cache/sci-biology/bedtools-2.30.0 b/metadata/md5-cache/sci-biology/bedtools-2.30.0
index 9aec2bcc8705..f717a41648bf 100644
--- a/metadata/md5-cache/sci-biology/bedtools-2.30.0
+++ b/metadata/md5-cache/sci-biology/bedtools-2.30.0
@@ -11,5 +11,5 @@ RDEPEND=app-arch/bzip2 app-arch/xz-utils sys-libs/zlib
 RESTRICT=!test? ( test )
 SLOT=0
 SRC_URI=https://github.com/arq5x/bedtools2/releases/download/v2.30.0/bedtools-2.30.0.tar.gz
-_eclasses_=multilib	d410501a125f99ffb560b0c523cd3d1e	python-any-r1	0a79a9b53fce4525f438f8ea9695fb88	python-utils-r1	69861348186337fa4b269de5826004b3	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
+_eclasses_=multilib	d410501a125f99ffb560b0c523cd3d1e	python-any-r1	0a79a9b53fce4525f438f8ea9695fb88	python-utils-r1	2dc8e06a3429719b43e9140f7292a425	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
 _md5_=14bf1e3697276975f4e8b47a297b1bf5
diff --git a/metadata/md5-cache/sci-biology/biopandas-0.2.7 b/metadata/md5-cache/sci-biology/biopandas-0.2.7
index 7595bf5d5d47..69d4cd620409 100644
--- a/metadata/md5-cache/sci-biology/biopandas-0.2.7
+++ b/metadata/md5-cache/sci-biology/biopandas-0.2.7
@@ -11,5 +11,5 @@ REQUIRED_USE=|| ( python_targets_python3_7 python_targets_python3_8 python_targe
 RESTRICT=!test? ( test ) !test? ( test )
 SLOT=0
 SRC_URI=mirror://pypi/B/BioPandas/biopandas-0.2.7.tar.gz
-_eclasses_=distutils-r1	c166cdc9bfdc0fee3ea2100e01fdcdd3	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	python-r1	4c65b35c1895b82c0f44e44166a3464f	python-utils-r1	69861348186337fa4b269de5826004b3	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
+_eclasses_=distutils-r1	16579e06f8839831bd5c03455bb87e3f	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	python-r1	6d099888c5b4dd4868c26508df307e95	python-utils-r1	2dc8e06a3429719b43e9140f7292a425	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
 _md5_=6e4b8600d4f3c3ac26b099a9c4577ca0
diff --git a/metadata/md5-cache/sci-biology/biopython-1.77 b/metadata/md5-cache/sci-biology/biopython-1.77
index 56e19af182db..1fe0f094f3a3 100644
--- a/metadata/md5-cache/sci-biology/biopython-1.77
+++ b/metadata/md5-cache/sci-biology/biopython-1.77
@@ -11,5 +11,5 @@ RDEPEND=dev-python/matplotlib[python_targets_python3_7(-)?,python_targets_python
 REQUIRED_USE=|| ( python_targets_python3_7 python_targets_python3_8 python_targets_python3_9 )
 SLOT=0
 SRC_URI=mirror://pypi/b/biopython/biopython-1.77.tar.gz
-_eclasses_=distutils-r1	c166cdc9bfdc0fee3ea2100e01fdcdd3	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	optfeature	6a2add34e06e5a05d88471a33ccdd73e	python-r1	4c65b35c1895b82c0f44e44166a3464f	python-utils-r1	69861348186337fa4b269de5826004b3	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
+_eclasses_=distutils-r1	16579e06f8839831bd5c03455bb87e3f	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	optfeature	6a2add34e06e5a05d88471a33ccdd73e	python-r1	6d099888c5b4dd4868c26508df307e95	python-utils-r1	2dc8e06a3429719b43e9140f7292a425	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
 _md5_=d8b830da081a300c996803cc6fafb594
diff --git a/metadata/md5-cache/sci-biology/embassy-cbstools-1.0.0.660 b/metadata/md5-cache/sci-biology/embassy-cbstools-1.0.0.660
index f08c77c8439d..7254b9d9ce30 100644
--- a/metadata/md5-cache/sci-biology/embassy-cbstools-1.0.0.660
+++ b/metadata/md5-cache/sci-biology/embassy-cbstools-1.0.0.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/CBSTOOLS-1.0.0.660.tar.gz -> embassy-cbstools-1.0.0.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=4166ba28131fdf70907b31300aa4c08b
diff --git a/metadata/md5-cache/sci-biology/embassy-clustalomega-1.1.0.660 b/metadata/md5-cache/sci-biology/embassy-clustalomega-1.1.0.660
index 84a8e470dfa0..6ef2680c8bae 100644
--- a/metadata/md5-cache/sci-biology/embassy-clustalomega-1.1.0.660
+++ b/metadata/md5-cache/sci-biology/embassy-clustalomega-1.1.0.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=sci-biology/clustal-omega dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/CLUSTALOMEGA-1.1.0.660.tar.gz -> embassy-clustalomega-1.1.0.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=ef491b452e56be12961f62b16961f4f1
diff --git a/metadata/md5-cache/sci-biology/embassy-domainatrix-0.1.660 b/metadata/md5-cache/sci-biology/embassy-domainatrix-0.1.660
index 104db0322526..e1a4f9fc35ed 100644
--- a/metadata/md5-cache/sci-biology/embassy-domainatrix-0.1.660
+++ b/metadata/md5-cache/sci-biology/embassy-domainatrix-0.1.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/DOMAINATRIX-0.1.660.tar.gz -> embassy-domainatrix-0.1.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=bfee4f5b2b2adadb41de2eb02d4dcbc0
diff --git a/metadata/md5-cache/sci-biology/embassy-domalign-0.1.660 b/metadata/md5-cache/sci-biology/embassy-domalign-0.1.660
index 8e7801bb7477..b741d1b8293d 100644
--- a/metadata/md5-cache/sci-biology/embassy-domalign-0.1.660
+++ b/metadata/md5-cache/sci-biology/embassy-domalign-0.1.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/DOMALIGN-0.1.660.tar.gz -> embassy-domalign-0.1.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=9f8b2caa273f4ae3b0463e6de6782660
diff --git a/metadata/md5-cache/sci-biology/embassy-domsearch-0.1.660 b/metadata/md5-cache/sci-biology/embassy-domsearch-0.1.660
index b5443bf28fc0..8e5c80c8f0aa 100644
--- a/metadata/md5-cache/sci-biology/embassy-domsearch-0.1.660
+++ b/metadata/md5-cache/sci-biology/embassy-domsearch-0.1.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/DOMSEARCH-0.1.660.tar.gz -> embassy-domsearch-0.1.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=920906439fbc5278460201b23a615736
diff --git a/metadata/md5-cache/sci-biology/embassy-emnu-1.05.660 b/metadata/md5-cache/sci-biology/embassy-emnu-1.05.660
index 5e372f068204..3a93ec14b1bc 100644
--- a/metadata/md5-cache/sci-biology/embassy-emnu-1.05.660
+++ b/metadata/md5-cache/sci-biology/embassy-emnu-1.05.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=ncurses? ( sys-libs/ncurses:0= ) dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/EMNU-1.05.660.tar.gz -> embassy-emnu-1.05.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=d82c7c44ec76fa5d6165769a73e5df9a
diff --git a/metadata/md5-cache/sci-biology/embassy-esim4-1.0.0.660 b/metadata/md5-cache/sci-biology/embassy-esim4-1.0.0.660
index 27386f4ac037..d9159cc25543 100644
--- a/metadata/md5-cache/sci-biology/embassy-esim4-1.0.0.660
+++ b/metadata/md5-cache/sci-biology/embassy-esim4-1.0.0.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/ESIM4-1.0.0.660.tar.gz -> embassy-esim4-1.0.0.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=1b156bed7ea031aeb5464836dd987f18
diff --git a/metadata/md5-cache/sci-biology/embassy-hmmer-2.3.2.660 b/metadata/md5-cache/sci-biology/embassy-hmmer-2.3.2.660
index 2f8c54d6b06f..0975b989a480 100644
--- a/metadata/md5-cache/sci-biology/embassy-hmmer-2.3.2.660
+++ b/metadata/md5-cache/sci-biology/embassy-hmmer-2.3.2.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=sci-biology/hmmer:2 dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/HMMER-2.3.2.660.tar.gz -> embassy-hmmer-2.3.2.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=83d02ae22d4e1864669639d9289cd112
diff --git a/metadata/md5-cache/sci-biology/embassy-iprscan-4.3.1.660 b/metadata/md5-cache/sci-biology/embassy-iprscan-4.3.1.660
index a4470fb64a8a..aadf7fdd1df2 100644
--- a/metadata/md5-cache/sci-biology/embassy-iprscan-4.3.1.660
+++ b/metadata/md5-cache/sci-biology/embassy-iprscan-4.3.1.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/IPRSCAN-4.3.1.660.tar.gz -> embassy-iprscan-4.3.1.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
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 _md5_=73b0c29964ea3506d18ef6b6c8df70e1
diff --git a/metadata/md5-cache/sci-biology/embassy-mse-3.0.0.660 b/metadata/md5-cache/sci-biology/embassy-mse-3.0.0.660
index a64404b36b2b..1ccd54a465ef 100644
--- a/metadata/md5-cache/sci-biology/embassy-mse-3.0.0.660
+++ b/metadata/md5-cache/sci-biology/embassy-mse-3.0.0.660
@@ -1,7 +1,8 @@
+BDEPEND=>=app-portage/elt-patches-20170815 || ( >=sys-devel/automake-1.16.2-r1:1.16 ) >=sys-devel/autoconf-2.69 >=sys-devel/libtool-2.4
 DEFINED_PHASES=configure install prepare
-DEPEND=>=app-portage/elt-patches-20170815 || ( >=sys-devel/automake-1.16.2-r1:1.16 ) >=sys-devel/autoconf-2.69 >=sys-devel/libtool-2.4 dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
+DEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 DESCRIPTION=EMBOSS integrated version of MSE - Multiple Sequence Screen Editor
-EAPI=6
+EAPI=7
 HOMEPAGE=http://emboss.sourceforge.net/
 IUSE=ncurses mysql pdf png postgres static-libs X
 KEYWORDS=~amd64 ~x86 ~x86-linux
@@ -9,5 +10,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=ncurses? ( sys-libs/ncurses:0= ) dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/MSE-3.0.0.660.tar.gz -> embassy-mse-3.0.0.660.tar.gz
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-_md5_=84df94b7c4b0f044de45cef524cbf453
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	multilib	d410501a125f99ffb560b0c523cd3d1e	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	wrapper	4251d4c84c25f59094fd557e0063a974
+_md5_=d12c79c0d0054aecac7a987e9b5f5655
diff --git a/metadata/md5-cache/sci-biology/embassy-phylipnew-3.69.660 b/metadata/md5-cache/sci-biology/embassy-phylipnew-3.69.660
index 41d9bf30d7e3..17a99c6d94f7 100644
--- a/metadata/md5-cache/sci-biology/embassy-phylipnew-3.69.660
+++ b/metadata/md5-cache/sci-biology/embassy-phylipnew-3.69.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2 free-noncomm
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/PHYLIPNEW-3.69.660.tar.gz -> embassy-phylipnew-3.69.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=5f78f83387f741c46031c218b1965467
diff --git a/metadata/md5-cache/sci-biology/embassy-signature-0.1.660 b/metadata/md5-cache/sci-biology/embassy-signature-0.1.660
index fa42c44cb599..26787c488c47 100644
--- a/metadata/md5-cache/sci-biology/embassy-signature-0.1.660
+++ b/metadata/md5-cache/sci-biology/embassy-signature-0.1.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/SIGNATURE-0.1.660.tar.gz -> embassy-signature-0.1.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=4cb685046b5a39b624eb3467b815c2c4
diff --git a/metadata/md5-cache/sci-biology/embassy-structure-0.1.660 b/metadata/md5-cache/sci-biology/embassy-structure-0.1.660
index 644165669f37..c80a8f98ee52 100644
--- a/metadata/md5-cache/sci-biology/embassy-structure-0.1.660
+++ b/metadata/md5-cache/sci-biology/embassy-structure-0.1.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/STRUCTURE-0.1.660.tar.gz -> embassy-structure-0.1.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=634d624be78f958ed7fca02e7dc43bd4
diff --git a/metadata/md5-cache/sci-biology/embassy-topo-2.0.660 b/metadata/md5-cache/sci-biology/embassy-topo-2.0.660
index b8a95d8066ad..7961d6be4811 100644
--- a/metadata/md5-cache/sci-biology/embassy-topo-2.0.660
+++ b/metadata/md5-cache/sci-biology/embassy-topo-2.0.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/TOPO-2.0.660.tar.gz -> embassy-topo-2.0.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=e50220ee11093554b589c1f9f53e7c09
diff --git a/metadata/md5-cache/sci-biology/embassy-vienna-1.7.2.660 b/metadata/md5-cache/sci-biology/embassy-vienna-1.7.2.660
index 43c7339eb276..95a18e38f163 100644
--- a/metadata/md5-cache/sci-biology/embassy-vienna-1.7.2.660
+++ b/metadata/md5-cache/sci-biology/embassy-vienna-1.7.2.660
@@ -9,5 +9,5 @@ LICENSE=LGPL-2 GPL-2
 RDEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt ) >=sci-biology/emboss-6.6.0-r1[mysql=,pdf=,png=,postgres=,static-libs=,X=]
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/VIENNA-1.7.2.660.tar.gz -> embassy-vienna-1.7.2.660.tar.gz
-_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	8895be811ae4511c202bcf2ddb7dbfd8	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
+_eclasses_=autotools	9988ecbe04129214297a7bbf3d253710	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	emboss-r2	79fb8dbd6c9c5dc48900a9319e493b02	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	libtool	f143db5a74ccd9ca28c1234deffede96	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974
 _md5_=d257de40bcdb33c0735daac8a5f15fda
diff --git a/metadata/md5-cache/sci-biology/emboss-6.6.0-r1 b/metadata/md5-cache/sci-biology/emboss-6.6.0-r1
index 58fc8a73f92c..51bc94575d44 100644
--- a/metadata/md5-cache/sci-biology/emboss-6.6.0-r1
+++ b/metadata/md5-cache/sci-biology/emboss-6.6.0-r1
@@ -1,7 +1,8 @@
+BDEPEND=>=app-portage/elt-patches-20170815 || ( >=sys-devel/automake-1.16.2-r1:1.16 ) >=sys-devel/autoconf-2.69 >=sys-devel/libtool-2.4
 DEFINED_PHASES=configure install postinst prepare
-DEPEND=>=app-portage/elt-patches-20170815 || ( >=sys-devel/automake-1.16.2-r1:1.16 ) >=sys-devel/autoconf-2.69 >=sys-devel/libtool-2.4 dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt )
+DEPEND=dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt )
 DESCRIPTION=The European Molecular Biology Open Software Suite - A sequence analysis package
-EAPI=6
+EAPI=7
 HOMEPAGE=http://emboss.sourceforge.net/
 IUSE=minimal mysql pdf png postgres static-libs X
 KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
@@ -10,5 +11,5 @@ PDEPEND=!minimal? ( sci-biology/aaindex sci-biology/cutg sci-biology/primer3 sci
 RDEPEND=!games-action/xbomber !sys-devel/cons dev-libs/expat dev-libs/libpcre:3 sci-libs/plplot:= sys-libs/zlib mysql? ( dev-db/mysql-connector-c:0= ) pdf? ( media-libs/libharu:= ) png? ( media-libs/gd:2=[png] ) postgres? ( dev-db/postgresql:= ) X? ( x11-libs/libXt )
 SLOT=0
 SRC_URI=ftp://emboss.open-bio.org/pub/EMBOSS/EMBOSS-6.6.0.tar.gz
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-_md5_=99a47266a2a8f2fd0a874111491146e2
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+_md5_=72c86b427ea83b8feb792884f23feaf3
diff --git a/metadata/md5-cache/sci-biology/express-1.5.1 b/metadata/md5-cache/sci-biology/express-1.5.1
index 5f4117b9a9bc..6d8306b35118 100644
--- a/metadata/md5-cache/sci-biology/express-1.5.1
+++ b/metadata/md5-cache/sci-biology/express-1.5.1
@@ -1,12 +1,13 @@
+BDEPEND=dev-util/ninja dev-util/cmake
 DEFINED_PHASES=compile configure install prepare test
-DEPEND=>=dev-libs/boost-1.52.0:= dev-libs/protobuf dev-util/google-perftools sci-biology/bamtools sys-libs/zlib sys-devel/make >=dev-util/cmake-3.9.6
+DEPEND=>=dev-libs/boost-1.52.0:= dev-libs/protobuf dev-util/google-perftools sci-biology/bamtools sys-libs/zlib
 DESCRIPTION=Streaming RNA-Seq Analysis
-EAPI=6
-HOMEPAGE=http://bio.math.berkeley.edu/eXpress/
+EAPI=7
+HOMEPAGE=https://pachterlab.github.io/eXpress/
 KEYWORDS=~amd64 ~x86
 LICENSE=Artistic
 RDEPEND=>=dev-libs/boost-1.52.0:= dev-libs/protobuf dev-util/google-perftools sci-biology/bamtools sys-libs/zlib
 SLOT=0
-SRC_URI=http://bio.math.berkeley.edu/eXpress/downloads/express-1.5.1/express-1.5.1-src.tgz
-_eclasses_=cmake-utils	77cd39e6009811bf97a59d91ffd5b54f	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	ninja-utils	132cbb376048d079b5a012f5467c4e7f	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	ff2ff954e6b17929574eee4efc5152ba
-_md5_=10c478f1e1a9a533322963cf4c2e92f8
+SRC_URI=https://pachterlab.github.io/eXpress/downloads/express-1.5.1/express-1.5.1-src.tgz
+_eclasses_=cmake	314a813be2f09820e8978cdee941e501	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	ninja-utils	132cbb376048d079b5a012f5467c4e7f	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	ff2ff954e6b17929574eee4efc5152ba
+_md5_=b4fcbc714ea460615318f4baa4bc347a
diff --git a/metadata/md5-cache/sci-biology/fasttree-2.1.11 b/metadata/md5-cache/sci-biology/fasttree-2.1.11
new file mode 100644
index 000000000000..9120be699408
--- /dev/null
+++ b/metadata/md5-cache/sci-biology/fasttree-2.1.11
@@ -0,0 +1,13 @@
+BDEPEND=dev-util/ninja dev-util/cmake
+DEFINED_PHASES=compile configure install prepare test unpack
+DESCRIPTION=Fast inference of approximately-maximum-likelihood phylogenetic trees
+EAPI=7
+HOMEPAGE=http://www.microbesonline.org/fasttree/
+IUSE=double-precision openmp cpu_flags_x86_sse3
+KEYWORDS=~amd64 ~x86
+LICENSE=GPL-2
+REQUIRED_USE=?? ( double-precision cpu_flags_x86_sse3 )
+SLOT=0
+SRC_URI=http://www.microbesonline.org/fasttree/FastTree-2.1.11.c http://www.microbesonline.org/fasttree/FastTreeUPGMA.c -> FastTreeUPGMA-2.1.11.c http://www.microbesonline.org/fasttree/MOTreeComparison.tar.gz -> MOTreeComparison-2.1.11.tar.gz
+_eclasses_=cmake	314a813be2f09820e8978cdee941e501	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	ninja-utils	132cbb376048d079b5a012f5467c4e7f	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	ff2ff954e6b17929574eee4efc5152ba
+_md5_=4a94b8db43f0aadb5ece67757ccbe635
diff --git a/metadata/md5-cache/sci-biology/fasttree-2.1.8 b/metadata/md5-cache/sci-biology/fasttree-2.1.8
deleted file mode 100644
index 49705a655e42..000000000000
--- a/metadata/md5-cache/sci-biology/fasttree-2.1.8
+++ /dev/null
@@ -1,13 +0,0 @@
-DEFINED_PHASES=compile configure install prepare test unpack
-DEPEND=sys-devel/make >=dev-util/cmake-3.9.6
-DESCRIPTION=Fast inference of approximately-maximum-likelihood phylogenetic trees
-EAPI=6
-HOMEPAGE=http://www.microbesonline.org/fasttree/
-IUSE=double-precision openmp cpu_flags_x86_sse3
-KEYWORDS=~amd64 ~x86
-LICENSE=GPL-2
-REQUIRED_USE=?? ( double-precision cpu_flags_x86_sse3 )
-SLOT=0
-SRC_URI=http://www.microbesonline.org/fasttree/FastTree-2.1.8.c http://www.microbesonline.org/fasttree/FastTreeUPGMA.c -> FastTreeUPGMA-2.1.8.c http://www.microbesonline.org/fasttree/MOTreeComparison.tar.gz -> MOTreeComparison-2.1.8.tar.gz
-_eclasses_=cmake-utils	77cd39e6009811bf97a59d91ffd5b54f	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	ninja-utils	132cbb376048d079b5a012f5467c4e7f	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	ff2ff954e6b17929574eee4efc5152ba
-_md5_=5a3e768febbbadcd5c8a4141dd49e11c
diff --git a/metadata/md5-cache/sci-biology/phylip-3.698 b/metadata/md5-cache/sci-biology/phylip-3.698
index c3318f0e5bcc..e264d51db1dd 100644
--- a/metadata/md5-cache/sci-biology/phylip-3.698
+++ b/metadata/md5-cache/sci-biology/phylip-3.698
@@ -10,4 +10,4 @@ RDEPEND=x11-libs/libXaw !dev-lang/elixir
 SLOT=0
 SRC_URI=http://evolution.gs.washington.edu/phylip/download/phylip-3.698.zip
 _eclasses_=edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	multilib	d410501a125f99ffb560b0c523cd3d1e	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	wrapper	4251d4c84c25f59094fd557e0063a974
-_md5_=f07202d933c062edd63457ffd0cde777
+_md5_=b3a777c086ea4a6cd489efcb5bde7b66
diff --git a/metadata/md5-cache/sci-biology/pysam-0.16.0.1 b/metadata/md5-cache/sci-biology/pysam-0.16.0.1
index bdd418edf1f6..d1b8aba0dc1a 100644
--- a/metadata/md5-cache/sci-biology/pysam-0.16.0.1
+++ b/metadata/md5-cache/sci-biology/pysam-0.16.0.1
@@ -12,5 +12,5 @@ REQUIRED_USE=|| ( python_targets_python3_7 python_targets_python3_8 python_targe
 RESTRICT=!test? ( test )
 SLOT=0
 SRC_URI=https://github.com/pysam-developers/pysam/archive/v0.16.0.1.tar.gz -> pysam-0.16.0.1.tar.gz
-_eclasses_=distutils-r1	c166cdc9bfdc0fee3ea2100e01fdcdd3	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	python-r1	4c65b35c1895b82c0f44e44166a3464f	python-utils-r1	69861348186337fa4b269de5826004b3	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
+_eclasses_=distutils-r1	16579e06f8839831bd5c03455bb87e3f	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	python-r1	6d099888c5b4dd4868c26508df307e95	python-utils-r1	2dc8e06a3429719b43e9140f7292a425	toolchain-funcs	24921b57d6561d87cbef4916a296ada4
 _md5_=24cbd77fb49bf7dfa36311bf5973256d
diff --git a/metadata/md5-cache/sci-biology/seqan-2.4.0 b/metadata/md5-cache/sci-biology/seqan-2.4.0
deleted file mode 100644
index 859fba476cd4..000000000000
--- a/metadata/md5-cache/sci-biology/seqan-2.4.0
+++ /dev/null
@@ -1,14 +0,0 @@
-DEFINED_PHASES=compile configure install prepare setup test
-DEPEND=app-arch/bzip2:= sys-libs/zlib:= !!sci-biology/seqan:2.0 !!sci-biology/seqan:2.1 !!sci-biology/seqan:2.2 dev-util/ninja >=dev-util/cmake-3.9.6
-DESCRIPTION=C++ Sequence Analysis Library
-EAPI=6
-HOMEPAGE=http://www.seqan.de/
-IUSE=cpu_flags_x86_sse4_1 tools
-KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
-LICENSE=BSD GPL-3
-RDEPEND=app-arch/bzip2:= sys-libs/zlib:= !!sci-biology/seqan:2.0 !!sci-biology/seqan:2.1 !!sci-biology/seqan:2.2
-REQUIRED_USE=cpu_flags_x86_sse4_1
-SLOT=0
-SRC_URI=https://github.com/seqan/seqan/archive/seqan-v2.4.0.tar.gz
-_eclasses_=cmake-utils	77cd39e6009811bf97a59d91ffd5b54f	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	ninja-utils	132cbb376048d079b5a012f5467c4e7f	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	ff2ff954e6b17929574eee4efc5152ba
-_md5_=f4fd93f51141b17b6915c7b5b28cc1b4
diff --git a/metadata/md5-cache/sci-biology/seqan-2.4.0-r1 b/metadata/md5-cache/sci-biology/seqan-2.4.0-r1
new file mode 100644
index 000000000000..ee69a5d36d4a
--- /dev/null
+++ b/metadata/md5-cache/sci-biology/seqan-2.4.0-r1
@@ -0,0 +1,15 @@
+BDEPEND=dev-util/ninja dev-util/cmake
+DEFINED_PHASES=compile configure install prepare setup test
+DEPEND=app-arch/bzip2:= sys-libs/zlib !!sci-biology/seqan:2.0 !!sci-biology/seqan:2.1 !!sci-biology/seqan:2.2
+DESCRIPTION=C++ Sequence Analysis Library
+EAPI=7
+HOMEPAGE=https://www.seqan.de/
+IUSE=cpu_flags_x86_sse4_1 tools
+KEYWORDS=~amd64 ~x86 ~amd64-linux ~x86-linux
+LICENSE=BSD GPL-3
+RDEPEND=app-arch/bzip2:= sys-libs/zlib !!sci-biology/seqan:2.0 !!sci-biology/seqan:2.1 !!sci-biology/seqan:2.2
+REQUIRED_USE=cpu_flags_x86_sse4_1
+SLOT=0
+SRC_URI=https://github.com/seqan/seqan/archive/seqan-v2.4.0.tar.gz
+_eclasses_=cmake	314a813be2f09820e8978cdee941e501	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	ninja-utils	132cbb376048d079b5a012f5467c4e7f	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	ff2ff954e6b17929574eee4efc5152ba
+_md5_=8796fa7c1594d16d8a9b96920de5cf2b
diff --git a/metadata/md5-cache/sci-biology/seqan-9999 b/metadata/md5-cache/sci-biology/seqan-9999
deleted file mode 100644
index a1d3494a788c..000000000000
--- a/metadata/md5-cache/sci-biology/seqan-9999
+++ /dev/null
@@ -1,13 +0,0 @@
-DEFINED_PHASES=compile configure install prepare setup test unpack
-DEPEND=app-arch/bzip2:= sys-libs/zlib:= !!sci-biology/seqan:2.0 !!sci-biology/seqan:2.1 !!sci-biology/seqan:2.2 dev-util/ninja >=dev-util/cmake-3.9.6 >=dev-vcs/git-1.8.2.1[curl]
-DESCRIPTION=C++ Sequence Analysis Library
-EAPI=6
-HOMEPAGE=http://www.seqan.de/
-IUSE=cpu_flags_x86_sse4_1 tools
-LICENSE=BSD GPL-3
-PROPERTIES=live
-RDEPEND=app-arch/bzip2:= sys-libs/zlib:= !!sci-biology/seqan:2.0 !!sci-biology/seqan:2.1 !!sci-biology/seqan:2.2
-REQUIRED_USE=cpu_flags_x86_sse4_1
-SLOT=0
-_eclasses_=cmake-utils	77cd39e6009811bf97a59d91ffd5b54f	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	git-r3	3e7ec3d6619213460c85e2aa48398441	l10n	8cdd85e169b835d518bc2fd59f780d8e	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multibuild	6b3d5ee849dafe6cdfd7b859c211fb01	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	ninja-utils	132cbb376048d079b5a012f5467c4e7f	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	ff2ff954e6b17929574eee4efc5152ba
-_md5_=894809b96951695cbe345aa3e8298ed2
diff --git a/metadata/md5-cache/sci-biology/uchime-4.2.40 b/metadata/md5-cache/sci-biology/uchime-4.2.40
index 834358283d89..1d891eff3909 100644
--- a/metadata/md5-cache/sci-biology/uchime-4.2.40
+++ b/metadata/md5-cache/sci-biology/uchime-4.2.40
@@ -1,12 +1,12 @@
+BDEPEND=dev-util/ninja dev-util/cmake
 DEFINED_PHASES=compile configure install prepare test
-DEPEND=sys-devel/make >=dev-util/cmake-3.9.6
 DESCRIPTION=Fast, accurate chimera detection
-EAPI=6
-HOMEPAGE=http://www.drive5.com/uchime/
+EAPI=7
+HOMEPAGE=https://www.drive5.com/usearch/manual/uchime_algo.html
 IUSE=debug
 KEYWORDS=amd64 x86 ~amd64-linux ~x86-linux
 LICENSE=public-domain
 SLOT=0
-SRC_URI=http://drive5.com/uchime/uchime4.2.40_src.tar.gz
-_eclasses_=cmake-utils	77cd39e6009811bf97a59d91ffd5b54f	desktop	c0d27bf73aa08ca05b663dbd31fbef28	edos2unix	33e347e171066657f91f8b0c72ec8773	epatch	e8f1ec13660dc2f44b32775765d85e42	estack	055c42df72f76a4f45ec92b35e83cd56	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	ltprune	4f3f2db5ce3ccbeeacdf3f94954043aa	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	ninja-utils	132cbb376048d079b5a012f5467c4e7f	preserve-libs	ef207dc62baddfddfd39a164d9797648	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	vcs-clean	2a0f74a496fa2b1552c4f3398258b7bf	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	ff2ff954e6b17929574eee4efc5152ba
-_md5_=6adcbb8c658bdc3c40f797c61f5c58b0
+SRC_URI=https://www.drive5.com/uchime/uchime4.2.40_src.tar.gz
+_eclasses_=cmake	314a813be2f09820e8978cdee941e501	edos2unix	33e347e171066657f91f8b0c72ec8773	eutils	2d5b3f4b315094768576b6799e4f926e	flag-o-matic	09a8beb8e6a8e02dc1e1bd83ac353741	l10n	8cdd85e169b835d518bc2fd59f780d8e	multilib	d410501a125f99ffb560b0c523cd3d1e	multiprocessing	cac3169468f893670dac3e7cb940e045	ninja-utils	132cbb376048d079b5a012f5467c4e7f	toolchain-funcs	24921b57d6561d87cbef4916a296ada4	wrapper	4251d4c84c25f59094fd557e0063a974	xdg-utils	ff2ff954e6b17929574eee4efc5152ba
+_md5_=854887494464770d2ebd028de122105d