diff -Naur a/src/python/grpcio/grpc/_cython/_cygrpc/aio/callback_common.pxd.pxi b/src/python/grpcio/grpc/_cython/_cygrpc/aio/callback_common.pxd.pxi
--- a/src/python/grpcio/grpc/_cython/_cygrpc/aio/callback_common.pxd.pxi	2024-03-05 18:46:12.903254598 +0800
+++ b/src/python/grpcio/grpc/_cython/_cygrpc/aio/callback_common.pxd.pxi	2024-03-05 18:46:42.989252881 +0800
@@ -48,7 +48,7 @@
     @staticmethod
     cdef void functor_run(
             grpc_completion_queue_functor* functor,
-            int succeed)
+            int succeed) noexcept
 
     cdef grpc_completion_queue_functor *c_functor(self)
 
diff -Naur a/src/python/grpcio/grpc/_cython/_cygrpc/aio/callback_common.pyx.pxi b/src/python/grpcio/grpc/_cython/_cygrpc/aio/callback_common.pyx.pxi
--- a/src/python/grpcio/grpc/_cython/_cygrpc/aio/callback_common.pyx.pxi	2024-03-05 18:46:12.903254598 +0800
+++ b/src/python/grpcio/grpc/_cython/_cygrpc/aio/callback_common.pyx.pxi	2024-03-05 18:47:00.094251906 +0800
@@ -50,7 +50,7 @@
     @staticmethod
     cdef void functor_run(
             grpc_completion_queue_functor* functor,
-            int success):
+            int success) noexcept:
         cdef CallbackContext *context = <CallbackContext *>functor
         cdef object waiter = <object>context.waiter
         if not waiter.cancelled():
diff -Naur a/src/python/grpcio/grpc/_cython/_cygrpc/credentials.pyx.pxi b/src/python/grpcio/grpc/_cython/_cygrpc/credentials.pyx.pxi
--- a/src/python/grpcio/grpc/_cython/_cygrpc/credentials.pyx.pxi	2024-03-05 18:46:12.903254598 +0800
+++ b/src/python/grpcio/grpc/_cython/_cygrpc/credentials.pyx.pxi	2024-03-05 18:48:02.097248368 +0800
@@ -316,7 +316,7 @@
   return credentials
 
 cdef grpc_ssl_certificate_config_reload_status _server_cert_config_fetcher_wrapper(
-        void* user_data, grpc_ssl_server_certificate_config **config) with gil:
+        void* user_data, grpc_ssl_server_certificate_config **config) noexcept with gil:
   # This is a credentials.ServerCertificateConfig
   cdef ServerCertificateConfig cert_config = None
   if not user_data:
diff -Naur a/src/python/grpcio/grpc/_cython/_cygrpc/fork_posix.pxd.pxi b/src/python/grpcio/grpc/_cython/_cygrpc/fork_posix.pxd.pxi
--- a/src/python/grpcio/grpc/_cython/_cygrpc/fork_posix.pxd.pxi	2024-03-05 18:46:12.902254598 +0800
+++ b/src/python/grpcio/grpc/_cython/_cygrpc/fork_posix.pxd.pxi	2024-03-05 19:16:29.155150966 +0800
@@ -12,10 +12,10 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-cdef void __prefork() nogil
+cdef void __prefork() noexcept nogil
 
 
-cdef void __postfork_parent() nogil
+cdef void __postfork_parent() noexcept nogil
 
 
-cdef void __postfork_child() nogil
\ No newline at end of file
+cdef void __postfork_child() noexcept nogil
\ No newline at end of file
diff -Naur a/src/python/grpcio/grpc/_cython/_cygrpc/fork_posix.pyx.pxi b/src/python/grpcio/grpc/_cython/_cygrpc/fork_posix.pyx.pxi
--- a/src/python/grpcio/grpc/_cython/_cygrpc/fork_posix.pyx.pxi	2024-03-05 18:46:12.903254598 +0800
+++ b/src/python/grpcio/grpc/_cython/_cygrpc/fork_posix.pyx.pxi	2024-03-05 19:17:17.124148229 +0800
@@ -35,7 +35,7 @@
 
 _fork_handler_failed = False
 
-cdef void __prefork() nogil:
+cdef void __prefork() noexcept nogil:
     with gil:
         global _fork_handler_failed
         _fork_handler_failed = False
@@ -49,14 +49,14 @@
             _fork_handler_failed = True
 
 
-cdef void __postfork_parent() nogil:
+cdef void __postfork_parent() noexcept nogil:
     with gil:
         with _fork_state.fork_in_progress_condition:
             _fork_state.fork_in_progress = False
             _fork_state.fork_in_progress_condition.notify_all()
 
 
-cdef void __postfork_child() nogil:
+cdef void __postfork_child() noexcept nogil:
     with gil:
         try:
             if _fork_handler_failed:
diff -Naur a/src/python/grpcio/grpc/_cython/_cygrpc/vtable.pyx.pxi b/src/python/grpcio/grpc/_cython/_cygrpc/vtable.pyx.pxi
--- a/src/python/grpcio/grpc/_cython/_cygrpc/vtable.pyx.pxi	2024-03-05 18:46:12.903254598 +0800
+++ b/src/python/grpcio/grpc/_cython/_cygrpc/vtable.pyx.pxi	2024-03-05 19:17:53.735146140 +0800
@@ -13,16 +13,16 @@
 # limitations under the License.
 
 # TODO(https://github.com/grpc/grpc/issues/15662): Reform this.
-cdef void* _copy_pointer(void* pointer):
+cdef void* _copy_pointer(void* pointer) noexcept:
   return pointer
 
 
 # TODO(https://github.com/grpc/grpc/issues/15662): Reform this.
-cdef void _destroy_pointer(void* pointer):
+cdef void _destroy_pointer(void* pointer) noexcept:
   pass
 
 
-cdef int _compare_pointer(void* first_pointer, void* second_pointer):
+cdef int _compare_pointer(void* first_pointer, void* second_pointer) noexcept:
   if first_pointer < second_pointer:
     return -1
   elif first_pointer > second_pointer: