Better way would probably be to have renpy not even try to write to system paths in the first place.

13: EACCES (no write permission)
30: EROFS (read-only filesystem)

diff --git a/renpy/script.py b/renpy/script.py
index 3e5dae8..8f103c1 100644
--- a/renpy/script.py
+++ b/renpy/script.py
@@ -656,6 +656,10 @@ class Script(object):
                                 rpydigest = hashlib.md5(fullf.read()).digest()
 
                             self.write_rpyc_md5(f, rpydigest)
+                    except OSError as e:
+                        if e.errno not in [13, 30]:
+                            import traceback
+                            traceback.print_exc()
                     except Exception:
                         import traceback
                         traceback.print_exc()
-- 
2.37.1